With or Without you

What does U2's most famous song "With or Without you" mean?

This 1987 hit single often went through mixed interpretation, but as confirmed by the songwriter Bono himself that the song is about his struggle to reconcile his responsibilities both as a married man and as a musician on road.
He cannot let go of either of it at the same time he cannot go on with it. That is why it says 'I can't live with our without you'

credit and source: Ishanu Dhar